Key result
Obesity was associated with significantly reduced enzymatic activities and protein levels of mitochondrial citrate synthase in human omental adipose tissue compared to nonobese controls.
Why the study?
Does obesity affect mitochondrial enzyme activities and ATP generation in human omental adipose tissue compared to nonobese controls?
Observational (n=135)
Does obesity affect mitochondrial enzyme activities and ATP generation in human omental adipose tissue compared to nonobese controls?
Obesity is associated with reduced mitochondrial citrate synthase activity and protein levels in human omental adipose tissue, suggesting an impact on the tricarboxylic acid cycle.
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Reduced adipose citrate synthase in obesity may signal mitochondrial impairment; leaves open causal role and need for longitudinal confirmation.
Christe et al. (2013) conducted an observational in Obesity (n=135). Obesity vs. Nonobese controls was evaluated on Enzymatic activities and protein levels of citrate synthase. Obesity was associated with significantly reduced enzymatic activities and protein levels of mitochondrial citrate synthase in human omental adipose tissue compared to nonobese controls.
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