Key result
Vitamin D deficiency in type 2 diabetes was associated with lower brachial flow-mediated dilation (MD -1.43%; 95% CI -2.31 to -0.55; P=0.001) and reduced endothelial progenitor cell counts.
Why the study?
Is Vitamin D deficiency associated with reduced brachial flow-mediated dilation and circulating endothelial progenitor cells in patients with type 2 diabetes?
Cross-Sectional (n=280)
Is Vitamin D deficiency associated with reduced brachial flow-mediated dilation and circulating endothelial progenitor cells in patients with type 2 diabetes?
Mean Difference: -1.43 (95% CI -2.31–-0.55)
p-value: p=0.001
Vitamin D deficiency is associated with endothelial dysfunction and depletion of circulating endothelial progenitor cells in patients with type 2 diabetes.
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Suggests vitamin D deficiency may worsen endothelial function in T2D; hypothesis-generating and does not change practice.
Yiu et al. (2011) conducted a cross-sectional in Type 2 diabetes mellitus (n=280). Vitamin D deficiency vs. Sufficient Vitamin D status was evaluated on Brachial flow-mediated dilation (FMD) (MD -1.43%, 95% CI -2.31 to -0.55, p=0.001). Vitamin D deficiency in type 2 diabetes was associated with lower brachial flow-mediated dilation (MD -1.43%; 95% CI -2.31 to -0.55; P=0.001) and reduced endothelial progenitor cell counts.
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