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July 22, 2010The Journal of Clinical Endocrinology & MetabolismOpen Access

A 16-Week Randomized Clinical Trial of 2000 International Units Daily Vitamin D3Supplementation in Black Youth: 25-Hydroxyvitamin D, Adiposity, and Arterial Stiffness

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Why the study?

Does Vitamin D3 supplementation 2000 IU/day improve arterial stiffness and 25(OH)D concentrations in normotensive black youth compared to 400 IU/day?

Population

49 normotensive black boys and girls, aged 16.3 ± 1.4 years

Comparison

Vitamin D3 supplementation 2000 IU/day for 16… vs Vitamin D3 supplementation 400 IU/day for 16 weeks

Design

RCT, randomly assigned, blinded

Follow-up

16 weeks

Authors

YDYanbin DongChinese Academy of SciencesISInger Stallmann‐JorgensenAugusta UniversityNPNorman K. PollockBoston Medical Center

Discussion

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Implication

May warrant 2000 IU/day vitamin D3 to limit aortic stiffening in normotensive black youth; extends RCT evidence on dose-dependent vascular effects.

Key Points

  • To assess the 25-hydroxyvitamin D response to 2000 IU daily vitamin D3 supplementation over 16 weeks, evaluate its relationship with body fat mass, and determine its effect on arterial stiffness in Black youth.
  • Randomized, blinded, controlled trial involving 49 normotensive Black adolescents (mean age 16.3 ± 1.4 years).
  • Participants were randomly assigned to receive either 400 IU/d (control group; n = 24) or 2000 IU/d (experimental group; n = 25) of oral vitamin D3 for 16 weeks.
  • Primary assessments included plasma 25-hydroxyvitamin D [25(OH)D], total body fat mass via dual-energy x-ray absorptiometry, and carotid-femoral pulse wave velocity (PWV) at baseline and follow-up.
  • Plasma 25(OH)D concentrations increased from 33.1 ± 8.7 to 85.7 ± 30.1 nmol/L in the 2000 IU/d group compared with 34.0 ± 10.6 to 59.8 ± 18.2 nmol/L in the 400 IU/d control group, reaching significantly higher levels in the experimental group at 8 and 16 weeks.
  • Carotid-femoral PWV decreased from 5.41 ± 0.73 to 5.33 ± 0.79 m/sec in the 2000 IU/d group (P = 0.031), whereas it increased from 5.38 ± 0.53 to 5.71 ± 0.75 m/sec in the 400 IU/d control group (P = 0.016).
  • Baseline total body fat mass was significantly and inversely associated with circulating 25(OH)D concentration gains across time in response to 2000 IU/d supplementation.

Structured PICO

Does Vitamin D3 supplementation 2000 IU/day improve arterial stiffness and 25(OH)D concentrations in normotensive black youth compared to 400 IU/day?

P
Population
49 normotensive black boys and girls, aged 16.3 ± 1.4 years
I
Intervention
Vitamin D3 supplementation 2000 IU/day for 16 weeks
C
Comparator
Vitamin D3 supplementation 400 IU/day for 16 weeks
O
Outcome
25-hydroxyvitamin D [25(OH)D] concentrations, relation between 25(OH)D and total body fat mass, and arterial stiffness measured by pulse wave velocity (PWV) over 16 weekssurrogate

Daily 2000 IU vitamin D3 supplementation may be effective in optimizing vitamin D status and counteracting the progression of aortic stiffness in black youth.

Cite This Study

Dong et al. (2010) studied this question.

synapsesocial.com/papers/6a7046dd26a7f98052dcc787https://doi.org/10.1210/jc.2010-0606

Topics

Women and heart disease
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