Why the study?
Observational studies link reduced serum 25(OH)D to increased cardiometabolic disease risk, but provide limited causal evidence, with few conclusive RCTs conducted.
Does vitamin D3 supplementation improve arterial stiffness in overweight/obese adult males with low vitamin D?
Population
55 healthy males aged 18–65 years with plasma 25(OH)D <75 nmol L–1 and BMI ≥24.9 kg m–2
Design
Pilot randomised controlled trial
Follow-up
8 weeks
Authors
Loading...
Vitamin D3 supplementation raises 25(OH)D without improving vascular function or cardiometabolic markers in healthy men; challenges observational causality and leaves open effects in deficient or higher-risk groups.
Does vitamin D3 supplementation improve arterial stiffness in overweight/obese adult males with low vitamin D?
High-dose vitamin D3 supplementation for 8 weeks in overweight/obese men with low vitamin D did not improve arterial stiffness but modestly reduced brachial pulse pressure.
Agbalalah et al. (2022) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: