Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 30, 2018Journal of the American Heart AssociationOpen Access

Effect of Vitamin D Supplementation on Markers of Vascular Function: A Systematic Review and Individual Participant Meta‐Analysis

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does Vitamin D supplementation improve markers of vascular function in participants of randomized trials?

Population

31 randomized trials pooling 2,751 participants

Comparison

Vitamin D supplementation for 4 weeks to 12 months vs Placebo

Design

Meta-analysis, randomized trials, placebo-controlled

Follow-up

4 weeks to 12 months

Authors

LBLouise A BeveridgeFKFaisel KhanASAllan D. Struthers

Discussion

Loading...

Member takes

Overview

Vitamin D supplementation shows no benefit on vascular function markers; challenges observational CV risk links and leaves outcome trials needed.

Structured PICO

Does Vitamin D supplementation improve markers of vascular function in participants of randomized trials?

P
Population
31 randomized trials pooling 2,751 participants
I
Intervention
Vitamin D supplementation (Vitamin D3 daily dose equivalents ranging from 900 to 5000 IU) for 4 weeks to 12 months
C
Comparator
Placebo
O
Outcome
Markers of vascular function including flow-mediated dilatation of the brachial artery, pulse wave velocity, augmentation index, central blood pressure, microvascular function, and reactive hyperemia indexsurrogate

Vitamin D supplementation does not significantly improve macrovascular or microvascular function markers, suggesting no direct vascular benefit.

Cite This Study

Beveridge et al. (2018) studied this question.

synapsesocial.com/papers/6a700cc6fe4101aa97dffd55https://doi.org/10.1161/jaha.117.008273
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Meta‐Analysis on the Effect of Vitamin D Supplementation on Endothelial Function in Adults2025 · 4 citations
  2. 2A Prospective Randomized Controlled Trial of the Effects of Vitamin D Supplementation on Cardiovascular Disease Risk2012 · 187 citations
  3. 3The impact of vitamin D supplement intake on vascular endothelial function; a systematic review and meta-analysis of randomized controlled trials2017 · 37 citations
  4. 4The Effects of Vitamin D Supplementation on Markers Related to Endothelial Function Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Clinical Trials2018 · 17 citations
  5. 5Effect of regulated vitamin D increase on vascular markers in patients with chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials2023 · 7 citations