What question did this study set out to answer?

To evaluate the efficacy of vitamin D supplementation in ameliorating arterial stiffness by synthesizing findings from randomized controlled trials.

January 29, 2016Clinical EndocrinologyOpen Access

Effect of vitamin D supplementation on measures of arterial stiffness: a systematic review and meta‐analysis of randomized controlled trials

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Why the study?

Does vitamin D supplementation reduce arterial stiffness as measured by pulse wave velocity and augmentation index?

Population

18 randomized controlled trials pooling up to 806 patients, investigating the effect of vitamin D…

Comparison

Vitamin D supplementation for 1-12 months. vs Control group.

Design

Meta-analysis

Follow-up

1-12 months

Authors

ARAlexander J. RodríguezFlorida International University DSDavid ScottDeakin University VSVelandai SrikanthBroad Institute

Discussion

Member takes

Implication

No support for vitamin D to reduce arterial stiffness; leaves open targeted trials in deficient subgroups.

Key Points

To evaluate the efficacy of vitamin D supplementation in ameliorating arterial stiffness by synthesizing findings from randomized controlled trials.
Searched MEDLINE, Scopus, and EMBASE databases for randomized controlled trials measuring pulse wave velocity (PWV) or augmentation index (AI) following vitamin D supplementation.
Identified 18 eligible trials with high quality scores (modified Jadad scores 9–12 of 13), featuring doses of 1,000–5,700 IU/day, follow-up durations of 1–12 months, and sample sizes of n=29–183.
Meta-analyzed standardized mean differences (SMD) and 95% confidence intervals from 13 trials using inverse-variance random-effects models.
Vitamin D supplementation showed a non-significant reduction in pulse wave velocity (SMD = -0.10; 95% CI: -0.24, 0.04; P = 0.17; n = 806 across 10 studies).
Augmentation index also displayed a non-significant reduction favoring vitamin D (SMD = -0.15; 95% CI: -0.32, 0.02; P = 0.08; n = 551 across 8 studies).

Structured PICO

Does vitamin D supplementation reduce arterial stiffness as measured by pulse wave velocity and augmentation index?

Population

18 randomized controlled trials (13 with data for meta-analysis) pooling up to 806 patients, investigating the effect of vitamin D supplementation on arterial stiffness.

Intervention

Vitamin D supplementation (dosing protocol range: 1000-5700 IU/day) for 1-12 months.

Comparator

Control group (specifics not detailed in abstract).

Outcome

Pulse wave velocity (PWV) and/or augmentation index (AI) as indicators of arterial stiffness.surrogate

Vitamin D supplementation does not significantly improve pulse wave velocity or augmentation index, suggesting inconsistent evidence for its role in ameliorating arterial stiffness.

Limitations

Heterogeneity in study design (dosing protocol, follow-up times, sample size, recruitment strategies)

Cite This Study

Rodríguez et al. (2016) studied this question.

synapsesocial.com/papers/6a7e7519fdf6e9f1664d9110 https://doi.org/10.1111/cen.13031

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Effect of vitamin D supplementation on measures of arterial stiffness: a systematic review and meta‐analysis of randomized controlled trials

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Effect of vitamin D supplementation on measures of arterial stiffness: a systematic review and meta‐analysis of randomized controlled trials

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

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