What question did this study set out to answer?

To test whether circulating 25-hydroxyvitamin D levels are independently associated with central arterial stiffness in a normative aging population.

Arterial Stiffness and Vitamin D Levels: the Baltimore Longitudinal Study of Aging

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Why the study?

Are 25-hydroxyvitamin D levels associated with central arterial stiffness in a normative aging population?

To test whether circulating 25-hydroxyvitamin D levels are independently associated with central arterial stiffness in a normative aging population.
Conducted a cross-sectional analysis of 1,228 healthy volunteers (50% male; mean age 70 ± 12 years) from the Baltimore Longitudinal Study of Aging.
Evaluated vascular stiffness via carotid-femoral pulse wave velocity (PWV) alongside serum 25-hydroxyvitamin D (25-OH D) levels.
Adjusted multivariable models for demographics, season, physical activity, kidney function (eGFR), cardiovascular risk score, calcium/vitamin D supplements, serum calcium, and PTH levels.
A significant inverse association occurred between PWV and 25-OH D in primary analysis (adjusted r² = 0.27; β = -0.43; P = 0.001).
The inverse association remained significant after multivariable adjustment for lifestyle, renal function, cardiovascular risk factors, and mineral metabolism markers (adjusted r² = 0.34; β = -0.34; P = 0.04).

Are 25-hydroxyvitamin D levels associated with central arterial stiffness in a normative aging population?

Population

1228 healthy volunteers (50% males; age, 70±12 yr) of the Baltimore Longitudinal Study of Aging

Intervention

25-hydroxyvitamin D (25-OH D) levels

Outcome

Carotid-femoral pulse wave velocity (PWV)surrogate

Higher vitamin D levels are independently associated with lower arterial stiffness in a healthy aging population.

No takes yet. Share an insight, caveat, or question.

Does not support vitamin D supplementation for stiffness; leaves open causal effects in aging adults.

Giallauria et al. (2012) studied this question.

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