Key result
In elderly Chinese patients with hypertension, each 1-ng/mL decrease in 25-hydroxyvitamin D was independently associated with a 0.04 m/s increase in the cardio-ankle vascular index.
Why the study?
Elderly individuals with non-dipper hypertension have increased peripheral arterial stiffness, and the role of prevalent vitamin D deficiency in promoting this stiffness remains unclear.
Is a non-dipper hypertension pattern and reduced 25-hydroxyvitamin D associated with increased peripheral arterial stiffness in elderly hypertensive patients?
Cross-Sectional (n=155)
No
Is a non-dipper hypertension pattern and reduced 25-hydroxyvitamin D associated with increased peripheral arterial stiffness in elderly hypertensive patients?
Effect estimate: B -0.04 (95% CI -0.07 to -0.01)
p-value: p=0.02
In elderly Chinese patients, a non-dipper hypertension pattern is associated with vitamin D deficiency, which independently correlates with increased peripheral arterial stiffness.
Vitamin D assessment may be considered in elderly hypertensives with stiffness; leaves open whether supplementation improves arterial compliance pending prospective trials.
Elderly individuals with non-dipper hypertension are at high risk of cardiovascular disease because of increased stiffness of peripheral arteries. Since, vitamin D deficiency is prevalent in elderly Chinese. We examined whether reduced plasma levels of 25-hydroxyvitamin D [25(OH)D] may help promote this stiffness.Hypertensive patients at least 60 years old without history of peripheral arterial disease at our hospital were retrospectively divided into dipper and non-dipper groups according to the results of 24-hour ambulatory blood pressure monitoring. Plasma levels of 25(OH)D were measured by enzyme immunoassay. Peripheral arterial stiffness was measured based on the cardio-ankle vascular index (CAVI).Of the 155 patients enrolled, 95 (61.3%) were diagnosed with non-dipper hypertension and these patients had significantly lower plasma levels of 25(OH)D than the 60 patients with dipper hypertension (19.58 ± 5.97 vs 24.36 ± 6.95 nmol/L, P < .01) as well as significantly higher CAVI (8.46 ± 1.65 vs 7.56 ± 1.08 m/s, P < .01). Vitamin D deficiency was significantly more common among non-dipper patients (57.9% vs 31.7%, P < .01). Multivariate regression showed that age and 25(OH)D were independently related to CAVI, with each 1-ng/ml decrease in 25(OH)D associated with a CAVI increase of +0.04 m/s.Non-dipper hypertension is associated with vitamin D deficiency and reduced plasma levels of 25(OH)D. The latter may contribute to stiffening of peripheral arteries, increasing the risk of cardiovascular disease.
No takes yet. Share an insight, caveat, or question.
Gu et al. (2020) conducted a cross-sectional in Essential hypertension (n=155). 25-hydroxyvitamin D [25(OH)D] levels was evaluated on Cardio-ankle vascular index (CAVI) (B -0.04, 95% CI -0.07 to -0.01, p=0.02). In elderly Chinese patients with hypertension, each 1-ng/mL decrease in 25-hydroxyvitamin D was independently associated with a 0.04 m/s increase in the cardio-ankle vascular index.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: