Key result
Vitamin D deficiency in newly diagnosed hypertensive patients was associated with increased arterial stiffness, including higher pulse wave velocity (8.37 vs 6.9 m/s; P=0.001).
Why the study?
Vitamin D affects vascular endothelial function, blood pressure, and arterial stiffness, but the association between serum 25-hydroxyvitamin D levels and arterial stiffness in newly diagnosed hypertension required assessment.
Is vitamin D deficiency associated with increased arterial stiffness in newly diagnosed hypertensive patients?
Cross-Sectional (n=100)
Is vitamin D deficiency associated with increased arterial stiffness in newly diagnosed hypertensive patients?
Vitamin D deficiency is associated with increased arterial stiffness and higher nighttime systolic blood pressure in newly diagnosed hypertensive patients.
Answers are grounded in this paper and cite their sources.
Association warrants no practice change in hypertension; leaves open whether vitamin D repletion improves arterial stiffness.
OBJECTIVE: Vitamin D has beneficial effects on vascular endothelial function, blood pressure (BP) and arterial stiffness. Arterial stiffness increases in early-stage hypertensive patients and it is a strong predictor of cardiovascular morbidity and mortality. The purpose of this study was to assess the association between serum 25-hydroxyvitamin D (25-OH D) levels and arterial stiffness in patients with newly diagnosed hypertension. METHOD: Our study included 100 newly diagnosed hypertensive patients (63 male, 37 female and mean age: 51.7 ± 10.3 years) without cardiovascular disease, malignancy, chronic kidney disease and diabetes mellitus. Patients were divided into two groups: vitamin D deficiency group (<20 ng/ml) and normal vitamin D group (≥20 ng/ml). Twenty-four-hour, daytime and nighttime ambulatory BP readings were recorded. Mobil-O-Graph ARC solver algorithm was used to evaluate arterial stiffness parameters of pulse wave velocity (PWV) (m/s), augmentation index normalized with 75/min heart rate (Alx@75). RESULTS: Patients with vitamin D deficency had higher values of Alx@75 and PWV values (20.9 ± 9 vs. 16.8 ± 6.9, P = 0.018 and 8.37 ± 1.16 vs. 6.9 ± 0.9, P = 0.001, respectively) despite similar 24-hour ambulatory BP monitoring in both groups. Level of serum calcium was significantly higher in vitamin D deficiency group (9.5 ± 0.23 vs. 9.3 ± 0.12, P = 0.007). Nighttime SBP was higher in vitamin D deficiency group (133.2 ± 14.3 mmHg vs. 126.3 ± 17.2 mmHg; P = 0.03) and also, vitamin D deficiency group had non-dipping SBP pattern compared to normal Vitamin D group (P = 0.013). CONCLUSION: Vitamin D deficiency is associated with increased arterial stiffness in newly diagnosed hypertensive patients in terms of increased PWV and Alx@75 values.
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Çakal et al. (2020) conducted a cross-sectional in newly diagnosed hypertension (n=100). Vitamin D deficiency (<20 ng/ml) vs. Normal vitamin D (≥20 ng/ml) was evaluated on Pulse wave velocity (PWV) (m/s) (p=0.001). Vitamin D deficiency in newly diagnosed hypertensive patients was associated with increased arterial stiffness, including higher pulse wave velocity (8.37 vs 6.9 m/s; P=0.001).
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