What question did this study set out to answer?

To determine the effect of vitamin D supplementation on hypertension, hypercholesterolemia, and type 2 diabetes in older Australians.

January 25, 2026NutrientsOpen Access

Effect of Vitamin D Supplementation on Cardiometabolic Outcomes in Older Australian Adults—Results from the Randomized Controlled D-Health Trial

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Authors

BRBriony Duarte RomeroQIMR Berghofer Medical Research Institute CACecilia AriciUniversity of Brescia CBCatherine BaxterQIMR Berghofer Medical Research Institute

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Implication

Randomized controlled trial finds vitamin D supplementation does not reduce hypertension, cholesterol, or diabetes in older Australians, suggesting no clinical benefit.

Key Points

To determine the effect of vitamin D supplementation on hypertension, hypercholesterolemia, and type 2 diabetes in older Australians.
Conducted a randomized, double-blind, placebo-controlled trial with monthly 60,000 IU of vitamin D3.
Involved 21,315 participants aged 60-84 years, with follow-up after 6 months.
Used anti-hypertensive, lipid-modifying, or anti-diabetic drug initiation as surrogates for incidence.
Analyzed data via the Australian Pharmaceutical Benefits Scheme database and employed flexible parametric survival models.
10,964 participants analyzed for hypertension, with 2,672 developing the condition (24.4%).
12,126 participants analyzed for hypercholesterolemia, with 2,554 developing it (21.1%).
17,846 participants analyzed for type 2 diabetes, with 779 developing it (4.4%).
Vitamin D supplementation showed no significant effect on the incidence of hypertension (HR 1.00), hypercholesterolemia (HR 1.05), or T2D (HR 0.97).

Cite This Study

Romero et al. (2026) studied this question.

synapsesocial.com/papers/6975b229feba4585c2d6db6e https://doi.org/10.3390/nu18020357

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Implication

Randomized controlled trial finds vitamin D supplementation does not reduce hypertension, cholesterol, or diabetes in older Australians, suggesting no clinical benefit.

Effect of Vitamin D Supplementation on Cardiometabolic Outcomes in Older Australian Adults—Results from the Randomized Controlled D-Health Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

Effect of Vitamin D Supplementation on Cardiometabolic Outcomes in Older Australian Adults—Results from the Randomized Controlled D-Health Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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