Key result
Vitamin D3 fails to reduce PWV over placebo despite lowering systolic BP in obesity.
Why the study?
Previous studies have been inconsistent in demonstrating beneficial cardiovascular effects of vitamin D supplementation.
Does vitamin D3 supplementation improve central hemodynamic parameters and autonomic activity in obese or overweight individuals with low vitamin D levels?
RCT (n=53)
Double-blind
Randomized
No
Does vitamin D3 supplementation improve central hemodynamic parameters and autonomic activity in obese or overweight individuals with low vitamin D levels?
Absolute Event Rate: 7.4% vs 7.3%
p-value: p=0.255
Eight weeks of daily high-dose vitamin D supplementation in obese or overweight individuals with low vitamin D levels improved systolic blood pressure and autonomic balance.
Background Previous studies have been inconsistent in demonstrating beneficial cardiovascular effects of vitamin D supplementation. Objective To evaluate the effects of vitamin D3 supplementation on central hemodynamic parameters and autonomic activity in obese/overweight individuals with low vitamin D levels (<30ng/dl). Methods Adults 40-65 years old with body mass index ≥25<40 kg/m2 were enrolled in this prospective, randomized, double-blind clinical trial (NCT 05689632). Central hemodynamics was assessed using the oscillometric method (Mobil-O-Graph®), and heart rate variability using a Polar heart rate monitor (Kubios® software). Patients (n=53) received a placebo in the control group (CO, n=25) or vitamin D3 (VD, n=28) 7000 IU/day, and were evaluated before (W0) and after 8 weeks (W8) with a significance level of 0.05. Results The groups were homogeneous regarding age (51±6 vs 52±6 years, p=0.509) and vitamin D levels (22.8±4.9 vs 21.7±4.5ng/ml, p=0.590). At W8, the VD group had significantly higher levels of vitamin D (22.5 vs 35.6ng/ml, p<0.001). Only the VD group showed a significant reduction in systolic blood pressure (SBP; 123±15 vs 119±14mmHg, p=0.019) and alkaline phosphatase (213±55 vs 202±55mg/dl, p=0.012). The CO group showed an increase in augmentation pressure (AP: 9 vs 12 mmHg, p=0.028) and augmentation index (AIx: 26 vs 35%, p=0.020), which was not observed in the VD group (AP: 8 vs 8 mmHg, AIx: 26 vs 25%, p>0.05). VD group showed an increase in the parasympathetic nervous system index (PNSi) (-0.64±0.94 vs -0.16±1.10, p=0.028) and the R-R interval (866±138 vs 924±161 ms, p= 0.026). Conclusion In this sample, eight weeks of daily vitamin D supplementation resulted in an improvement in blood pressure levels and autonomic balance.
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Faria et al. (2024) conducted an RCT in Obesity or overweight with low vitamin D levels (n=53). Vitamin D3 vs. Placebo was evaluated on Pulse wave velocity (VOP) (p=0.255). Daily supplementation with 7000 IU of vitamin D3 for eight weeks in obese or overweight individuals significantly reduced systolic blood pressure and improved autonomic balance, despite no significant change in the primary endpoint of pulse wave velocity.
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