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October 1, 1990Journal of VirologyOpen Access

Functional analysis of the internal translation initiation site of foot-and-mouth disease virus

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Population

Foot-and-mouth disease virus genome (5' untranslated sequence)

Design

Preclinical

Authors

RKRichard KühnBavarian Academy of Sciences and HumanitiesNLNÁYRA RACHEL NASCIMENTO LUZPepsiCo (United Kingdom)EBEwald BeckGiessen School of Theology

Discussion

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Implication

May guide antiviral targeting of FMDV translation; leaves open extension to other picornaviruses.

Structured PICO

P
Population
Foot-and-mouth disease virus genome (5' untranslated sequence)
I
Intervention
Mutagenesis of the large untranslated sequence at the 5' end
O
Outcome
Translation efficiencysurrogate

Mutagenesis reveals that specific domains and a pyrimidine-rich sequence in the 5' untranslated region of the foot-and-mouth disease virus are essential for efficient internal translation initiation.

Cite This Study

Kühn et al. (1990) studied this question.

synapsesocial.com/papers/6a225cce7d05348b2ab600d3https://doi.org/10.1128/jvi.64.10.4625-4631.1990
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter1984 · 6,458 citations
  2. 2All foot and mouth disease virus serotypes initiate protein synthesis at two separate AUGs1987 · 118 citations
  3. 3A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation1988 · 1,377 citations
  4. 4Internal binding of eucaryotic ribosomes on poliovirus RNA: translation in HeLa cell extracts1989 · 128 citations
  5. 5A second protease of foot-and-mouth disease virus1986 · 183 citations