Key result
Acute l-citrulline ingestion significantly attenuated the increase in aortic systolic blood pressure during exercise and cold pressor testing compared to placebo (27 vs 38 mm Hg; P<0.05).
Why the study?
Hypertensive postmenopausal women exhibit exaggerated exercise SBP due to impaired functional sympatholysis, but whether acute L-citrulline attenuates aortic SBP and leg hemodynamic responses during exercise with sympathoactivation was unknown.
Does acute l-Citrulline ingestion attenuate aortic systolic blood pressure during exercise and sympathoactivation in hypertensive postmenopausal women?
RCT (n=15)
Randomly assigned
Does acute l-Citrulline ingestion attenuate aortic systolic blood pressure during exercise and sympathoactivation in hypertensive postmenopausal women?
Absolute Event Rate: 27% vs 38%
p-value: p=< 0.05
Acute l-citrulline supplementation attenuates aortic systolic blood pressure responses to exercise and cold-induced sympathetic activation in hypertensive postmenopausal women.
May warrant consideration to blunt exertional BP surges in hypertensive postmenopausal women; extends low-certainty RCT evidence from 125 patients.
PURPOSE: Hypertensive postmenopausal women (PMW) have exaggerated exercise systolic blood pressure (SBP) due to impaired functional sympatholysis. l-Citrulline (CIT) supplementation attenuates aortic SBP responses to cold pressor test (CPT)-induced vasoconstriction in young men. We hypothesized that acute CIT ingestion would attenuate aortic SBP and leg hemodynamic responses during exercise and CPT (EX + CPT). METHODS: Fifteen hypertensive PMW (61 ± 7 yr) were randomly assigned to consume either 6 g of CIT or placebo (PL) separated by a minimum 3-d washout phase. Brachial and aortic blood pressure, femoral artery blood flow (FBF), and vascular conductance (FVC) were measured at rest and during 5 min of unilateral plantarflexion exercise with a CPT applied during minutes 4 and 5. RESULTS: No differences between conditions were found in FBF, FVC, and brachial and aortic blood pressure at rest and during exercise alone. Changes in brachial SBP (CIT vs PL, 29 ± 12 vs 40 ± 10 mm Hg) and mean arterial pressure (CIT vs PL, 21 ± 10 vs 33 ± 11 mm Hg), and aortic SBP (CIT vs PL, 27 ± 11 vs 38 ± 9 mm Hg) and mean arterial pressure (CIT vs PL, 23 ± 9 vs 33 ± 11 mm Hg) to EX + CPT were lower in the CIT versus PL condition (P < 0.05). FBF, FVC, and functional sympatholysis (%ΔFVC) were not significantly different between conditions. CONCLUSIONS: Acute CIT ingestion attenuated aortic SBP response to exercise and cold-induced sympathetic activation that may prevent left ventricle overload in hypertensive PMW.
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Maharaj et al. (2022) conducted an RCT in Hypertension (n=15). l-Citrulline vs. Placebo was evaluated on Change in aortic systolic blood pressure during exercise and cold pressor test (mm Hg) (p=< 0.05). Acute l-citrulline ingestion significantly attenuated the increase in aortic systolic blood pressure during exercise and cold pressor testing compared to placebo (27 vs 38 mm Hg; P<0.05).
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