Key result
Nitric oxide and prostacyclin interact redundantly to regulate skeletal muscle blood flow during exercise, though a large part of exercise hyperaemia remains unexplained by known vasodilator systems.
Design
Review
Authors
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Redundant NO-prostacyclin regulation warrants no change in exercise management; leaves open identification of dominant unexplained vasodilators.
This review highlights the complex, redundant interactions between nitric oxide and prostacyclin in regulating skeletal muscle blood flow during exercise, while noting that significant mechanisms remain to be fully elucidated.
Hellsten et al. (2012) conducted a review in Exercise hyperaemia. Vasodilators (Nitric oxide and prostacyclin) was evaluated. Nitric oxide and prostacyclin interact redundantly to regulate skeletal muscle blood flow during exercise, though a large part of exercise hyperaemia remains unexplained by known vasodilator systems.
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