Key result
The onset of acute ST-elevation myocardial infarction exhibited significant circadian variation with peaks at 07:31-08:30, 14:31-15:30, and 23:31-00:30, as well as a monthly maximum in November.
Observational (n=1,467)
No
p-value: p=<0.001
In a Chinese population, the onset of STEMI exhibits significant diurnal, monthly, and seasonal variations, with three daily peaks and the highest frequency occurring in autumn.
Alerts clinicians to peak STEMI hours in Chinese populations; leaves open causal mechanisms and intervention trials.
OBJECTIVE: The objective of this study was to explore the time distribution patterns of the onset of chest pain in subjects with acute ST-elevation myocardial infarction in a Chinese population. METHODS: A total of 1467 patients with acute ST-elevation myocardial infarction were enrolled from 2003 to 2010. The hourly, daily, monthly, seasonal and day-of-week fluctuations in the prevalence of acute ST-elevation myocardial infarction were analyzed. RESULTS: A peak was found between the morning hours of 07:31 and 08:30. A second peak was observed between 14:31 and 15:30, and a third peak was found between 23:31 and 00:30 (p<0.001). The monthly maximum was recorded in November and the minimum was in April (p<0.001). The number of daily cases was greatest in autumn and lowest in the spring (p = 0.001). Day-of-the-week variations of ST-elevation acute myocardial infarction were not found, except in patients more than 75-years-old. CONCLUSIONS: Periodic variations in the frequency of ST-elevation acute myocardial infarction in Chinese patients showed significant differences with regard to diurnal, monthly and seasonal patterns. The exact mechanisms underlying these circadian variations require further study.
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Jia et al. (2012) conducted an observational in Acute ST-elevation myocardial infarction (n=1,467). Time of symptom onset (circadian, daily, monthly, seasonal) was evaluated on Time distribution patterns of the onset of chest pain (p=<0.001). The onset of acute ST-elevation myocardial infarction exhibited significant circadian variation with peaks at 07:31-08:30, 14:31-15:30, and 23:31-00:30, as well as a monthly maximum in November.
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