Reporting of Results in ClinicalTrials.gov and High-Impact Journals

Reporting of Results in ClinicalTrials.gov and High-Impact JournalsThe 2007 Food and Drug Administration (FDA) Amendments Act expanded requirements for ClinicalTrials.gov,a public clinical trial registry maintained by the National Library of Medicine, mandating results reporting within 12 months of trial completion for all FDA-regulated medical products.Reporting of mandatory trial registration information on ClinicalTrials.gov is fairly complete, although there are concerns about its specificity; optional trial registration information is less complete. 1-4To our knowledge, no studies have examined reporting and accuracy of trial results information.Accordingly, we compared trial information and results reported on ClinicalTrials.govwith corresponding peer-reviewed publications.