Key result
Persistent depression is linked to ~2.3-fold higher risk of recurrent ACS.
Why the study?
The study was conducted to examine the role of persistent symptoms of depression and anxiety in a second acute coronary syndrome event.
Does persistent depression or anxiety increase the risk of a recurrent acute coronary syndrome event in post-ACS patients?
Cohort (n=1,162)
Yes
Does persistent depression or anxiety increase the risk of a recurrent acute coronary syndrome event in post-ACS patients?
Persistent depression, especially when comorbid with anxiety, significantly increases the risk of recurrent ACS, highlighting the need for psychological assessment and management in secondary prevention.
Supports mental health assessment in post-ACS secondary prevention; extends observational links to recurrent events while leaving causality open.
The purpose of this study was to examine the role of persistent symptoms of depression and anxiety in a second acute coronary syndrome (ACS) event. Data presented in this study were from an RCT study. A follow-up for 24 months after baseline to detect a second ACS event among 1162 patients from five hospitals. Hierarchal Cox regression analyses were used. The results showed that persistent depression only (HR 2.27; 95% CI: 1.35–3.81; p = 0.002), and comorbid persistent depression and anxiety (HR 2.03; 95% CI: 1.03–3.98; p = 0.040) were the significant predictors of a second ACS event. Secondary education level compared to primary educational level (HR 0.63; 95% CI: 0.43–0.93; p = 0.020) and college or more education level compared to primary educational level (HR 0.47; 95% CI: 0.27–0.84; p = 0.011) were the only demographic variables that were significant predictors of a second event. The study reveals that attention must be paid by healthcare providers to assess and manage persistent depression; particularly when it is co-morbid with anxiety.
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Alhurani et al. (2022) conducted a cohort in Acute Coronary Syndrome (n=1,162). Persistent depression vs. No persistent depression or anxiety was evaluated on Second ACS event (HR 2.27, 95% CI 1.35-3.81, p=0.002). Persistent depression significantly increased the risk of a second acute coronary syndrome event (HR 2.27) compared to patients without persistent depression or anxiety.
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