What question did this study set out to answer?

This research investigates how tissue plasminogen activator (tPA) affects blood-brain barrier integrity during ischemic stroke and the role of PDGF-CC in this process.

June 22, 2008Nature MedicineOpen Access

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke

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This research investigates how tissue plasminogen activator (tPA) affects blood-brain barrier integrity during ischemic stroke and the role of PDGF-CC in this process.
Intraventricular injection of tPA or active PDGF-CC was performed in mice to assess cerebrovascular permeability.
Neutralizing antibodies to PDGF-CC were co-injected with tPA to evaluate their effects on permeability.
The PDGFR-α antagonist imatinib was administered after ischemic stroke to observe changes in cerebrovascular permeability and hemorrhagic complications.
Intraventricular injection of tPA significantly increased cerebrovascular permeability (p<0.01).
Co-injection of neutralizing antibodies to PDGF-CC with tPA blocked this increased permeability.
Treatment with imatinib reduced cerebrovascular permeability and hemorrhagic complications associated with late tPA administration.

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Implication

Randomized trial reveals tPA impairs blood-brain barrier in ischemic stroke, indicating new treatment strategies.

Cite This Study

Su et al. (2008) studied this question.

synapsesocial.com/papers/6a22644c8a4701dbb7910026 https://doi.org/10.1038/nm1787

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Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke

Key Points

Discussion

Implication

Cite This Study

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke

Key Points

Discussion

Implication

Cite This Study

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