Key result
Socioeconomic deprivation linked to ~5% higher 1-year mortality after AMI in patients with diabetes.
Why the study?
People from socio-economically deprived areas have worse post-AMI outcomes, but how deprivation influences survival in patients with diabetes mellitus after AMI is not well described.
Cohort (n=729,722)
Yes
Socio-economic deprivation is strongly associated with higher long-term mortality following acute myocardial infarction, though this disparity gap is notably smaller in patients with diabetes, suggesting structured chronic disease management may partially mitigate socioeconomic inequalities.
Deprivation-associated mortality risk after MI in diabetes warrants attention; extends prior observational data by showing a narrower gap than in non-diabetics.
BACKGROUND: People from areas of socio-economic deprivation have poorer outcomes following acute myocardial infarction (AMI). How deprivation influences the survival of people with diabetes mellitus (DM) post-AMI is not well described. METHODS: Using the Myocardial Ischaemia National Audit Project (MINAP) registry, with Office for National Statistics (ONS) mortality recording, 729,722 patients from England and Wales between 2005 and 2019 were included, 152,867 with DM and followed up to 31 July 2021. Patients were stratified into quintiles using the Index of Multiple Deprivation (IMD) score (Q1-most-deprived, Q5-least deprived), Cox regression models were fitted and adjusted mortality risk estimates were compared by IMD quintile and DM status. RESULTS: Thirty-day mortality risk between Q1 (most deprived) and Q5 (least deprived) was similar for patients with DM, but in patients without DM, risk was higher in the most deprived group (aHR: 1.05 (1.01-1.09), p < 0.001). Risk of 1-year (aHR: 1.05 (1.01-1.10), p < 0.001), 5-year (aHR: 1.14 (1.11-1.17), p < 0.001) and overall mortality (aHR: 1.14 (1.12-1.17), p < 0.001) was higher in Q1 compared to Q5 for patients with DM, but this increase was smaller than in patients without DM at 1 year (aHR: 1.12 (1.09-1.14), p < 0.001), 5 years (aHR: 1.18 (1.16-1.20), p < 0.001) and overall (aHR: 1.22 (1.20-1.23), p < 0.001). Adjusted 1-year mortality was higher in patients with DM than those without DM regardless of IMD quintile (e.g. DM vs. non-DM: Q1: 18.8% vs. 16.1%, Q5: 17.8% vs. 14.6%). CONCLUSION: Patients with DM from socio-economically deprived regions have a higher risk of mortality at 1 year, 5 years and overall, compared to least deprived patients with DM following AMI. However, the inequality gap was larger in the non-diabetic population, suggesting that current approaches to management in people with DM may mitigate some of the effect of deprivation on outcomes.
No takes yet. Share an insight, caveat, or question.
Weight et al. (2025) conducted a cohort in Acute myocardial infarction (with and without diabetes mellitus) (n=729,722). High socio-economic deprivation (Index of Multiple Deprivation Quintile 1) vs. Low socio-economic deprivation (Index of Multiple Deprivation Quintile 5) was evaluated on 1-year all-cause mortality (in patients with diabetes) (aHR 1.05, 95% CI 1.01-1.10, p=0.010). In patients with diabetes experiencing an acute myocardial infarction, high socio-economic deprivation was associated with an increased risk of 1-year mortality compared to the least deprived (aHR 1.05, 95% CI 1.01-1.10, p=0.010), though the inequality gap was larger in the non-diabetic population.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: