Why the study?
Does physical deconditioning (HDBR) or diuretic-induced hypovolaemia alter cortical activation patterns during baroreflex unloading?
Population
17 subjects (n=8 in Study 1, n=9 in Study 2) undergoing experimental baroreflex unloading
Comparison
24 h head-down-tilt bed rest or spironolactone… vs Pre-intervention baseline
Design
Randomly assigned lower body negative pressure treatments
Follow-up
24 hours (Study 1) and 3 days (Study 2)
Authors
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Distinguishes deconditioning from hypovolemia effects on baroreflex cortical control; hypothesis-generating for mechanistic studies before clinical relevance.
Does physical deconditioning (HDBR) or diuretic-induced hypovolaemia alter cortical activation patterns during baroreflex unloading?
Physical deconditioning induces rapid functional changes in cortical circuitry associated with cardiovascular control that are distinct from those caused by diuretic-induced hypovolaemia.
Shoemaker et al. (2012) studied this question.
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