Reveals the role of PVN oxytocin in modulating isoflurane-induced anesthesia, suggesting neural pathway interactions.
AIMS: -VTA pathway contribute to isoflurane-induced anesthetic state transitions is unknown. METHODS: Immunostaining and fiber photometry were used to verify the neuronal activity during the isoflurane anesthesia. Chemogenetic or optogenetic stimulation of PVN OXT neurons was then performed to verify their role in anesthesia, along with electroencephalography and behavioral recording. RESULTS: -VTA neural pathway produced similar effects. CONCLUSIONS: -VTA pathway plays a significant and unique part.
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Du et al. (2026) studied this question.
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