Why the study?
Does overexpression of phospholamban alter functional properties and calcium handling in isolated adult rat ventricular myocytes?
Population
Isolated adult rat ventricular myocytes (103 myocytes from 5 preparations)
Comparison
Adenoviral vector carrying the sequence for… vs 24-hour controls
Design
Preclinical
Follow-up
24 hours
Key result
Overexpression of phospholamban using an adenoviral vector in adult rat myocytes decreased maximum contraction amplitude to 6.9% compared with 11.2% in controls (P<0.001).
Authors
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Supports phospholamban modulation of myocyte function in rats; leaves open therapeutic targeting in human HF.
Does overexpression of phospholamban alter functional properties and calcium handling in isolated adult rat ventricular myocytes?
Absolute Event Rate: 6.9% vs 11.2%
p-value: p=<0.001
Overexpression of phospholamban in adult rat ventricular myocytes via adenoviral vector produces functional changes, including slowed relaxation and decreased contraction amplitude, similar to those seen in failing human hearts.
Davia et al. (1999) studied Isolated adult rat ventricular myocytes (n=103). Adenoviral vector carrying the sequence for phospholamban (Ad.RSV.PLB) vs. 24-h controls was evaluated on Maximum contraction amplitude (% shortening) (p=<0.001). Overexpression of phospholamban using an adenoviral vector in adult rat myocytes decreased maximum contraction amplitude to 6.9% compared with 11.2% in controls (P<0.001).