Population
Neonatal rat cardiomyocytes
Comparison
Recombinant adenovirus designed to overexpress… vs Uninfected or control cardiomyocytes
Design
Preclinical
Follow-up
48 hours
Key result
Adenovirus-mediated overexpression of phospholamban in rat cardiomyocytes prolonged the relaxation phase (710 vs 344 ms, P<0.01) and decreased peak intracellular calcium (630 vs 967 nmol/L, P<0.01).
Authors
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Does not inform clinical practice; leaves open phospholamban targeting in human HF models.
p-value: p=<.01
Overexpression of phospholamban in rat cardiomyocytes impairs intracellular Ca2+ handling, mimicking abnormalities seen in heart failure, which can be partially corrected by simultaneous SERCA2a overexpression.
Hajjar et al. (1997) studied Heart failure. Adenoviral gene transfer of phospholamban (Ad.RSV.PL) vs. Uninfected control cells was evaluated on Intracellular Ca2+ transients (relaxation phase, peak [Ca2+]i, resting [Ca2+]i) (p=<.01). Adenovirus-mediated overexpression of phospholamban in rat cardiomyocytes prolonged the relaxation phase (710 vs 344 ms, P<0.01) and decreased peak intracellular calcium (630 vs 967 nmol/L, P<0.01).