Crucial Role of Trigonal Pyramidal and Rigid Planar Donors in Croconaine Nanoprobe for Tumor NIR-II Fluorescence Imaging and High-Efficiency Phototherapy

Chengren Ouyang; Haixin Teng; Guanrong Ou; Jielin Yu; Qiuke Huang; Chun‐Qiong Zhou

doi:10.1021/acsami.6c03719

June 2, 2026ACS Applied Materials & Interfaces

Crucial Role of Trigonal Pyramidal and Rigid Planar Donors in Croconaine Nanoprobe for Tumor NIR-II Fluorescence Imaging and High-Efficiency Phototherapy

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Key Points

This research examines the role of specific donor structures in enhancing croconaine-based nanoprobes for tumor imaging and therapy.
Developed croconaine nanoparticles (CR-652 NPs) for testing.
Evaluated efficacy of NIR-II fluorescence imaging and photothermal therapy (PTT) under 808 nm irradiation.
Assessed the performance of type-I photodynamic therapy (PDT) in preclinical studies.
Achieved a high photoconversion efficiency (PCE) of 82% during irradiation.
Demonstrated that CR-652 NPs provided synergistic effects when combining type-I PDT with PTT.
Highlighted the effectiveness of donor-planar and non-planar engineering in targeting hypoxic-deep tumors.

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Implication

Explores fluorescence imaging and phototherapy in tumors, suggesting new design strategies for treatments.

Abstract

generation and a high PCE (82%) under irradiation (808 nm). In preclinical studies, CR-652 NPs exerted synergistic type-I PDT and amplified PTT. Overall, this work offers a promising perspective on the rational design of croconaine-based NIR-II phototheranostic agents for hypoxic-deep tumors by donor-planar and non-planar-engineering.

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Ouyang et al. (2026) studied this question.

synapsesocial.com/papers/6a2266f6763171746d545d42 https://doi.org/10.1021/acsami.6c03719

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Crucial Role of Trigonal Pyramidal and Rigid Planar Donors in Croconaine Nanoprobe for Tumor NIR-II Fluorescence Imaging and High-Efficiency Phototherapy

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Abstract

Discussion

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Crucial Role of Trigonal Pyramidal and Rigid Planar Donors in Croconaine Nanoprobe for Tumor NIR-II Fluorescence Imaging and High-Efficiency Phototherapy

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