Diradical-Featured N-Arene Croconaine-Based Nanoagent for Synergistic Photodynamic/Photothermal Tumor Therapy

Yiru Tang; Xiaoyu Zhu; Yating Zeng; Wanying Li; Na Hao; Ji Lu; Bowen Lei; Yao Jian; Lin Yang

doi:10.1039/d6tb01182a

January 1, 2026Journal of Materials Chemistry B

Diradical-Featured N-Arene Croconaine-Based Nanoagent for Synergistic Photodynamic/Photothermal Tumor Therapy

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Key Points

This research aims to develop a croconaine-based nanoagent for enhanced tumor treatment through photodynamic and photothermal therapy.
Developed a novel N-arene croconaine nanoagent with diradical features.
Tested synergistic effects of photodynamic therapy (PDT) and photothermal therapy (PTT) in vitro and in vivo.
Assessed stability and efficacy of the nanoagent under various conditions.
The croconaine-based nanoagent exhibited significant stability compared to traditional materials.
Enhanced tumor targeting achieved a greater reduction in tumor size compared to controls (specific rates not provided).
Combination therapy resulted in a synergistic effect, improving cytotoxicity against tumor cells significantly.

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Implication

Demonstrates enhanced tumor therapy efficacy with a new nanoagent, suggesting improved treatment outcomes.

Abstract

Organic radical materials with narrow bandgaps and small singlet-triplet energy gaps are ideal for synergistic photodynamic/photothermal therapy (PDT/PTT), but suffer from their poor stability. Croconaines (CRs), resonance-stabilized zwitterionic donor-acceptor-donor π-conjugated...

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Tang et al. (2026) studied this question.

synapsesocial.com/papers/6a3631a1db0793dc1a5386ba https://doi.org/10.1039/d6tb01182a

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Diradical-Featured N-Arene Croconaine-Based Nanoagent for Synergistic Photodynamic/Photothermal Tumor Therapy

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Diradical-Featured N-Arene Croconaine-Based Nanoagent for Synergistic Photodynamic/Photothermal Tumor Therapy

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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