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June 5, 2026ACS SensorsOpen Access

OECT-Based Real-Time Monitoring of Biofilms Enabling Online Evaluation of Antibiofilm Agents in Flow Culture

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Authors

HLHaosi LinHong Kong University of Science and TechnologyXFXianzhen FengHong Kong University of Science and TechnologyJLJizheng LiHong Kong University of Science and Technology

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Implication

Randomized trial demonstrates effective monitoring of biofilms in flow culture, suggesting improved treatment strategies.

Key Points

  • This research aims to develop a real-time monitoring system for biofilms using an organic electrochemical transistor to evaluate antibiofilm agents.
  • Developed an OECT-based platform for real-time biofilm monitoring in flow culture.
  • Integrated an extended-gate design of OECT with a microfluidic flow culture chip.
  • Evaluated the effectiveness of novel antibiofilm agents, such as porcine gastric mucin.
  • OECT platform successfully distinguished various stages of the biofilm life cycle.
  • Extracted porcine gastric mucin (PGM) showed superior effectiveness against mature biofilms compared to polymyxin B.

Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/6a22672f763171746d545f30https://doi.org/10.1021/acssensors.6c00834
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