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In Vitro Study Reveals Lignin's Inhibitory Effect on Colon Cancer Cells, Indicating Potential for Anticancer Materials.
Colorectal cancer poses a significant threat to human health. Here, lignin was isolated from the residues of four traditional Chinese medicinal herbs (cinnamon, sandalwood, agarwood, and Aucklandiae radix ) following aqueous extraction. The molecular weight distribution, elemental composition, and structural characteristics of these lignins were analyzed. An in vitro cell experiment system was established to investigate the inhibitory effects of lignin on human colon cancer cell lines (SW620, HT29, and HCT116) and normal cell lines (HaCaT, RAW264.7, and NCM460). Results demonstrated that lignin derived from traditional Chinese medicine residues significantly inhibited colon cancer cell proliferation in a concentration‐dependent manner. At 25 µg/mL, agarwood lignin (ACL) and Aucklandiae radix lignin (ARL) exhibited inhibition rates exceeding 94% against all three colon cancer cell lines, while causing minimal damage to normal cells. This study reveals the potent and selective inhibitory effect of TCM residue‐derived lignin on colon cancer cells, providing experimental evidence for developing anticancer functional materials.
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Liu et al. (2026) studied this question.
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