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Reports the presence of KRT10-nEDD-epidermolytic in a newborn, indicating a rare genetic condition.
Epidermal naevi arise because of cutaneous mosaicism. The epidermolytic variant of this naevus is a result of a postzygotic mutation in the KRT1 or KRT10 gene. Occasionally, this mutation can manifest in progeny as generalized KRT10-nonsyndromic epidermal differentiation disorder (nEED)-epidermolytic (formerly epidermolytic ichthyosis). We report an infant with KRT10-nEDD-epidermolytic and his father had an KRT10-nEDD-mosaic (formerly verrucous epidermal naevi) with a similar mutation in KRT10.
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P et al. (2026) studied this question.
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