Cefiderocol susceptibility in carbapenem-resistant Acinetobacter baumannii , Pseudomonas aeruginosa , and Stenotrophomonas maltophilia isolates: concordance of disk diffusion with the reference method and comparative analysis of CLSI-EUCAST criteria

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Key Points

The aim is to evaluate cefiderocol susceptibility in various carbapenem-resistant bacterial isolates and analyze the accuracy of disk diffusion testing compared to standard methods.
Evaluated cefiderocol effectiveness against carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia isolates.
Conducted disk diffusion assays and compared results with the minimum inhibitory concentration (MIC) reference method.
Applied CLSI-EUCAST criteria for susceptibility interpretation.
Disk diffusion showed reduced reliability in the 'grey zone', necessitating MIC confirmation.
Significant differences in susceptibility rates were found between the disk diffusion and reference methods.
CLSI-EUCAST criteria provided varied interpretations of susceptibility for different isolates.

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Analyzes cefiderocol effectiveness against resistant bacteria using disk diffusion and reference methods, suggesting the need for confirmatory tests.

, reduced reliability of DD in the 'grey zone' highlights the need for MIC confirmation.

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Saylam et al. (2026) studied this question.

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