Perforated acalculous cholecystitis in a neutropenic patient following chemotherapy: a fatal case report

Acalculous cholecystitis is an uncommon but serious complication of myelosuppressive chemotherapy that is most often observed during profound neutropenia and carries a substantially high morbidity and mortality. This case describes the fulminant course of acalculous cholecystitis in a 78-year-old female receiving carboplatin and vinorelbine for non-small cell lung cancer, with rapid progression from initial presentation to septic shock and multiorgan failure. The case highlights the aggressive nature of acalculous cholecystitis in immunocompromised patients and underscores the importance of early clinical suspicion and prompt intervention in preventing progression to catastrophic outcomes.