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Mathematical and experimental analysis reveals the impact of avidity on antibody binding in cell surfaces, suggesting implications for therapeutic applications.
binding data, we observed an affinity-dependent discrepancy between experimentally observed and model-predicted cell binding that we hypothesize arises due to unavoidable assay limitations. The calibrated model was then reused to correct for the assay bias and to generate refined estimates for on-cell antibody binding. The predictions generated by this model for the influence of avidity on cell surface receptor engagement with therapeutic antibodies may guide strategies for their structural engineering and dosing.
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Heirene et al. (2026) studied this question.
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