Beyond ACE2: unveiling the receptor-mediated endocytic dynamic mechanism of SARS-CoV-2 at the single-particle level

Q: What does this research mean for the field?

SARS-CoV-2 virus-like particles preferentially utilize BSG-mediated entry into ACE2-deficient HepG2 cells, despite higher expression levels of DPP4. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Xiaoyu Ma; Zhuang Zhang; Dandan Yang; Hui Wang; Hao Zhang; Yi Yang; Siying Li; Yuping Shan

doi:10.1039/d6tb00299d

January 1, 2026Journal of Materials Chemistry B

Beyond ACE2: unveiling the receptor-mediated endocytic dynamic mechanism of SARS-CoV-2 at the single-particle level

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Key Points

This research aims to investigate the dynamics of SARS-CoV-2 entry mechanisms beyond ACE2.
Examined SARS-CoV-2 VLPs in ACE2-deficient HepG2 cells.
Assessed the role of BSG in virus entry despite higher DPP4 expression.
SARS-CoV-2 VLPs preferentially entered cells through BSG, showing significant receptor engagement.
ACE2 deficiency did not prevent viral entry, indicating alternative pathways.

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Implication

Explores receptor engagement dynamics of SARS-CoV-2 in cell models, suggesting new pathways for targeting entry mechanisms.

Abstract

SARS-CoV-2 VLPs exhibit a preference for BSG-mediated entry into ACE2-deficient HepG2 cells, despite DPP4 being more highly expressed.

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Cite This Study

Ma et al. (2026) studied this question.

synapsesocial.com/papers/6a22695a763171746d547d45 https://doi.org/10.1039/d6tb00299d

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Beyond ACE2: unveiling the receptor-mediated endocytic dynamic mechanism of SARS-CoV-2 at the single-particle level

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Beyond ACE2: unveiling the receptor-mediated endocytic dynamic mechanism of SARS-CoV-2 at the single-particle level

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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