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June 5, 2026Current Treatment Options in PediatricsOpen Access

The Management of Neonatal Sepsis and Septic Shock

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Authors

EOEduardo Antônio de Sousa OrlandinLOLuis Kanhiti OharomariWGWalusa Assad Gonçalves‐Ferri

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Overview

Review highlights diagnostic and therapeutic strategies for neonatal sepsis and septic shock, suggesting improved outcomes through individualized care.

Key Points

  • This review examines the evolving management strategies for neonatal sepsis and septic shock, emphasizing the incorporation of new diagnostic tools and individualized care.
  • Discussion of various biomarkers for diagnosis and management, including C-reactive protein and procalcitonin.
  • Evaluation of imaging techniques like targeted neonatal echocardiography and point-of-care ultrasound to guide resuscitation.
  • Exploration of machine learning models for diagnostic performance and their limitations.
  • Biomarkers display limitations despite diagnostic utility for neonatal sepsis and septic shock.
  • Targeted ultrasound improves shock assessment, enhancing individualized treatment approaches.
  • Emphasis on antimicrobial stewardship and physiology-guided support proposes a shift toward personalized management.

Cite This Study

Orlandin et al. (2026) studied this question.

synapsesocial.com/papers/6a22696f763171746d547eechttps://doi.org/10.1007/s40746-026-00379-3
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