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Demonstrates effective deracemisation of drug precursor, suggesting improved synthesis methods.
Starting from a racemic building block, we introduce a one-pot mechanochemical synthesis of enantioenriched 2-(benzylideneamino)butanamide, a key intermediate to the enantipure drug levetiracetam. Optimisation leads to an ee of up...
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Leyssens et al. (2026) studied this question.
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