Key result
Higher endothelial lipase correlates with lower VLDL and IDL lipid content specifically in metabolic syndrome.
Why the study?
The association between serum levels of endothelial lipase and the levels and composition of apolipoprotein B-containing lipoproteins in healthy subjects and patients with metabolic syndrome remained unexplored.
Does metabolic syndrome alter the association between endothelial lipase and apoB-containing lipoproteins compared to healthy volunteers?
Cross-Sectional (n=130)
Yes
Does metabolic syndrome alter the association between endothelial lipase and apoB-containing lipoproteins compared to healthy volunteers?
Metabolic syndrome profoundly alters the association between endothelial lipase and apoB-containing lipoproteins, highlighting its potential role in the altered processing of VLDL and IDL particles in this patient population.
Endothelial lipase-VLDL/IDL correlations in metabolic syndrome require prospective validation; leaves open any causal role in remnant dyslipidemia.
The association between serum levels of endothelial lipase (EL) and the serum levels and composition of apolipoprotein B (apoB)-containing lipoproteins in healthy subjects and patients with metabolic syndrome (MS) remained unexplored. Therefore, in the present study, we determined the serum levels and lipid content of apoB-containing lipoproteins using nuclear magnetic resonance (NMR) spectroscopy and examined their association with EL serum levels in healthy volunteers (HVs) and MS patients. EL was significantly negatively correlated with the serum levels of cholesterol in large very low-density lipoprotein (VLDL) particles, as well as with total-cholesterol-, free-cholesterol-, triglyceride-, and phospholipid-contents of VLDL and intermediate-density lipoprotein particles in MS patients but not in HVs. In contrast, EL serum levels were significantly positively correlated with the serum levels of apoB, triglycerides, and phospholipids in large low-density lipoprotein particles in HVs but not in MS patients. EL serum levels as well as the serum levels and lipid content of the majority of apoB-containing lipoprotein subclasses were markedly different in MS patients compared with HVs. We conclude that EL serum levels are associated with the serum levels and lipid content of apoB-containing lipoproteins and that these associations are markedly affected by MS.
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Klobučar et al. (2023) conducted a cross-sectional in Metabolic Syndrome (n=130). Metabolic syndrome vs. Healthy volunteers was evaluated on Association between serum levels of endothelial lipase (EL) and the serum levels and lipid content of apoB-containing lipoproteins. Endothelial lipase serum levels were significantly negatively correlated with the cholesterol, triglyceride, and phospholipid contents of VLDL and IDL particles in metabolic syndrome patients but not in healthy volunteers.
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