Endothelial Lipase Concentrations Are Increased in Metabolic Syndrome and Associated with Coronary Atherosclerosis
Population
858 healthy individuals with a family history of premature coronary heart disease recruited as part of the…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Should not yet change practice; leaves open endothelial lipase as causal pro-atherogenic factor or target.
Structured PICO
P
Population
858 healthy individuals with a family history of premature coronary heart disease recruited as part of the Study of the Inherited Risk of Atherosclerosis.
O
Outcome
Association of endothelial lipase (EL) mass concentrations with metabolic syndrome factors and coronary artery calcification (CAC)surrogate
Endothelial lipase concentrations are significantly associated with metabolic syndrome features and subclinical atherosclerosis, suggesting it may be a pro-atherogenic factor in humans.
Cite This Study
Badellino et al. (2005) studied this question.