Endothelial Lipase Is Increased In Vivo by Inflammation in Humans
Why the study?
Does inflammation upregulate endothelial lipase in humans?
Population
858 healthy subjects recruited on the basis of family history of coronary disease; 20 subjects; and cultured…
Design
Cohort
Follow-up
12 to 16 hours (for endotoxemia study)
Authors
Discussion
Loading...
Member takes
Implication
Supports inflammation-driven EL upregulation as a mechanism for low HDL in metabolic disease; hypothesis-generating and requires causal confirmation before clinical consideration.
Structured PICO
Does inflammation upregulate endothelial lipase in humans?
P
Population
858 healthy subjects recruited on the basis of family history of coronary disease (observational cohort); 20 subjects (experimental endotoxemia cohort); and cultured human coronary endothelial cells.
I
Intervention
Experimental low-dose endotoxin injection (in 20 subjects)
O
Outcome
Plasma endothelial lipase (EL) concentrations and correlation with inflammatory markers (high-sensitivity C-reactive protein, interleukin 6, soluble tumor necrosis factor receptor II, soluble intercellular adhesion molecule 1, leptin, and adiponectin)surrogate
Inflammation directly upregulates endothelial lipase in humans, providing a potential mechanism for the low HDL cholesterol levels observed in obesity and metabolic syndrome.
Cite This Study
Badellino et al. (2008) studied this question.