January 1, 2007Journal of Atherosclerosis and ThrombosisOpen Access

Endothelial Lipase is Increased by Inflammation and Promotes LDL Uptake in Macrophages

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Why the study?

Does simvastatin reduce LPS-induced endothelial lipase expression and native LDL uptake in murine macrophages?

Structured PICO

Does simvastatin reduce LPS-induced endothelial lipase expression and native LDL uptake in murine macrophages?

Population

Murine peritoneal macrophages isolated from wild-type C57BL/6J (EL+/+) mice, EL-deficient (EL-/-) mice, LPS-resistant (tlr4 gene mutant) C3H/HeJ mice, and LPS-sensitive C3H/HeN mice

Intervention

Lipopolysaccharide (LPS) stimulation (10-1000 ng/mL) with or without simvastatin (0.1-10 μM)

Comparator

Unstimulated macrophages (vehicle control) or EL-/- macrophages

Outcome

Endothelial lipase (EL) mRNA expression and uptake of DiI-labeled native low-density lipoprotein (nLDL)surrogate

Simvastatin inhibits LPS-induced upregulation of endothelial lipase and subsequent native LDL uptake in macrophages, suggesting a novel anti-atherogenic mechanism for statins.

Discussion

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Implication

Hypothesis-generating for a novel statin mechanism in macrophages; leaves open translation to human atherosclerosis or practice change.

Cite This Study

Yasuda et al. (2007) studied this question.

synapsesocial.com/papers/6a7b6ae814b028facf0ed136 https://doi.org/10.5551/jat.e502

Topics

Statin therapy

View Full Paper

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Endothelial Lipase is Increased by Inflammation and Promotes LDL Uptake in Macrophages

Structured PICO

Discussion

Implication

Cite This Study

Topics

Endothelial Lipase is Increased by Inflammation and Promotes LDL Uptake in Macrophages

Structured PICO

Discussion

Implication

Cite This Study

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Topics

Keep reading