What question did this study set out to answer?

The study aims to explore how CETP and LPL polymorphisms affect lipid responses to dietary fat in men and women with familial hypercholesterolaemia.

June 26, 2009Lipids in Health and DiseaseOpen Access

Sex-associated effect of CETP and LPL polymorphisms on postprandial lipids in familial hypercholesterolaemia

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Authors

KAKatherine K. AnagnostopoulouTechnological Educational Institute of Piraeus GKGenovefa KolovouPreventive Cardiology PKPeggy KostakouNational and Kapodistrian University of Athens

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Implication

Randomized trial assessed gender-specific influences of genetic variants on lipid response in familial hypercholesterolaemia, suggesting implications for treatment.

Key Points

The study aims to explore how CETP and LPL polymorphisms affect lipid responses to dietary fat in men and women with familial hypercholesterolaemia.
Genotyped 80 heterozygous men and postmenopausal women for familial hypercholesterolaemia and 11 healthy controls.
Subgrouped individuals based on responses to an oral fat tolerance test measuring triglyceride levels.
Defined pathological response as triglyceride levels exceeding 220 mg/dl post-test.
In men with a pathological response, the incremental area under the curve was significantly higher than in women.
Multivariate analysis indicated a gender-specific influence of TaqIB and I405V on postprandial lipaemia in the pathological subgroup.
Men with the B2 allele exhibited higher triglyceride peaks and delayed return to baseline compared to women with the same allele.

Cite This Study

Anagnostopoulou et al. (2009) studied this question.

synapsesocial.com/papers/6a226a2db65eef78bdff5f46 https://doi.org/10.1186/1476-511x-8-24

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Implication

Randomized trial assessed gender-specific influences of genetic variants on lipid response in familial hypercholesterolaemia, suggesting implications for treatment.

Sex-associated effect of CETP and LPL polymorphisms on postprandial lipids in familial hypercholesterolaemia

Discussion

Member takes

Implication

Key Points

Cite This Study

Sex-associated effect of CETP and LPL polymorphisms on postprandial lipids in familial hypercholesterolaemia

Discussion

Member takes

Implication

Key Points

Cite This Study

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