Why the study?
Does the Ser447-Ter mutation of the lipoprotein lipase gene affect the variability of serum lipid and lipoprotein levels in monozygotic twins?
Population
54 male monozygotic twin pairs (n=108 individuals), aged 18-28 years
Comparison
Presence of the Ser447-Ter mutation of the… vs Absence of the mutation (CC genotype) (n=44 pairs)
Design
Cross-sectional
Authors
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May attenuate environmental lipid variability in twins; hypothesis-generating for LPL variants as restrictive genes.
Does the Ser447-Ter mutation of the lipoprotein lipase gene affect the variability of serum lipid and lipoprotein levels in monozygotic twins?
The Ser447-Ter mutation of the lipoprotein lipase gene is associated with attenuated variability in lipid levels in response to environmental stimuli, suggesting a restrictive variability gene effect.
Thorn et al. (1998) studied this question.
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