Twin Studies of Coronary Heart Disease and Its Risk Factors
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Key result
Monozygotic twins had a significantly higher concordance rate for coronary heart disease before age 60 compared to dizygotic twins, demonstrating a significant genetic influence on premature CHD.
Population
8,516 like-sexed Norwegian twin pairs born between 1915 and 1960 who completed an extensive health…
Design
Cohort
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Implication
Supports genetic predisposition to premature CHD; leaves open specific variant identification and clinical translation.
Study Design
Type
Observational (n=17,032)
Structured PICO
P
Population
Over 8,500 like-sexed Norwegian twin pairs born between 1915 and 1960 were evaluated to determine the genetic influence on coronary heart disease, hypertension, and lipid levels.
C
Comparator
Dizygotic (DZ) twins compared to Monozygotic (MZ) twins
O
Outcome
Concordance rates for coronary heart disease and hypertension, and heritability estimates for serum lipid and lipoprotein levels
Main Result
p-value: p=0.01 < P < 0.02
This large population-based twin study demonstrates a significant genetic influence on premature coronary heart disease, hypertension, and levels of atherogenic lipoproteins.
Limitations
- Hospital confirmed diagnoses were not yet available on death discordant pairs, relying on self-reported questionnaire data.
- Observed rates of concordance and discordance may be misleading at this transitory stage due to short observation periods for the second twin.
- Small sample sizes in some genetic marker subgroups necessitate cautious interpretation of lipid variability findings.
- Hospital confirmed diagnoses are not yet available on death discordant pairs
- Transitory stage of the study may make observed rates of concordance and discordance misleading
- Small numbers in some genetic marker subgroup analyses require cautious interpretation
Cite This Study
Kåre Berg (1984) conducted an observational in Coronary heart disease and its risk factors (n=17,032). Monozygotic twin status vs. Dizygotic twin status was evaluated on Concordance for coronary heart disease (angina pectoris and/or myocardial infarction) before age 60 (p=0.01 < P < 0.02). Monozygotic twins had a significantly higher concordance rate for coronary heart disease before age 60 compared to dizygotic twins, demonstrating a significant genetic influence on premature CHD.
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