Key result
Dizygotic twins exhibited a significantly greater total variance for high-density lipoprotein cholesterol compared to monozygotic twins over 16 years (p < 0.05), primarily driven by the HDL2 fraction.
Cohort
Effect estimate: Variance ratio 2.22
p-value: p=<0.05
The study demonstrates a significant difference in HDL-C variance between monozygotic and dizygotic twins, suggesting genetic and environmental influences on HDL fractions.
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Supports genetic regulation of HDL-C variance; leaves open whether variance informs risk stratification or therapy.
Christian et al. (1990) reported a cohort. Dizygotic zygosity vs. Monozygotic zygosity was evaluated on Total variance for high density lipoprotein cholesterol (HDL-C) (Variance ratio 2.22, p=<0.05). Dizygotic twins exhibited a significantly greater total variance for high-density lipoprotein cholesterol compared to monozygotic twins over 16 years (p < 0.05), primarily driven by the HDL2 fraction.
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