Key result
The association between systolic blood pressure and cardiovascular disease risk significantly increased with higher body mass index, reaching an HR of 1.63 per 1-SD increase in obese individuals.
Why the study?
Does the effect of blood pressure on the risk of cardiovascular disease vary by body mass index in Chinese adults?
Cohort (n=169,871)
Yes
Does the effect of blood pressure on the risk of cardiovascular disease vary by body mass index in Chinese adults?
Hazard Ratio: 1.63 (95% CI 1.51–1.76)
p-value: p=<0.0001
The magnitude of the association between blood pressure and cardiovascular disease risk increases with higher body mass index, indicating that hypertension is not a less serious risk factor in obese individuals compared to lean individuals.
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Supports vigilant BP control across BMI strata; extends observational data on effect modification but leaves causality open.
Wang et al. (2010) conducted a cohort in Cardiovascular disease (n=169,871). 1-SD increase in systolic blood pressure vs. Reference blood pressure was evaluated on Cardiovascular disease risk per 1-SD increase in systolic blood pressure in obese participants (HR 1.63, 95% CI 1.51-1.76, p=<0.0001). The association between systolic blood pressure and cardiovascular disease risk significantly increased with higher body mass index, reaching an HR of 1.63 per 1-SD increase in obese individuals.
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