Key result
Zero-contrast LAAC achieves 100% success in CKD patients without periprocedural complications or acute kidney disease.
Why the study?
LAAC usually requires contrast medium, placing patients with CKD at high risk of contrast nephropathy, so this study aimed to assess the safety and feasibility of zero-contrast LAAC in CKD.
Is zero-contrast left atrial appendage closure safe and feasible in patients with chronic kidney disease Stages 3b-5?
Observational (n=15)
No
Is zero-contrast left atrial appendage closure safe and feasible in patients with chronic kidney disease Stages 3b-5?
Zero-contrast left atrial appendage closure using TEE guidance is feasible and safe in patients with moderate to severe chronic kidney disease, avoiding the risk of contrast-induced nephropathy.
May support contrast-sparing LAA closure in advanced CKD; leaves open confirmation in prospective trials.
BACKGROUND: Left atrial appendage closure (LAAC) usually requires contrast medium during the procedure. However, patients with chronic kidney disease (CKD) are at high risk of developing contrast nephropathy. This study aimed to assess the safety and feasibility of zero-contrast LAAC in patients with CKD. METHODS AND RESULTS: Zero-contrast LAAC was attempted in 15 patients with CKD Stages 3b-5 who were not on hemodialysis. All procedures were performed successfully, without any periprocedural complications. At the 45-day follow-up, no device-related complications or acute kidney disease were observed. CONCLUSIONS: The strategy of zero-contrast LAAC in patients with CKD can be an acceptable option.
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Fukushima et al. (2023) conducted an observational in Chronic Kidney Disease and Atrial Fibrillation (n=15). Zero-contrast left atrial appendage closure was evaluated on Procedural success and periprocedural complications. Zero-contrast left atrial appendage closure was successfully performed in 100% of attempted cases in patients with chronic kidney disease, with no periprocedural complications or acute kidney disease observed at 45 days.
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