Key result
MAFLD linked to ~135% higher odds of concurrent carotid atherosclerosis versus non-MAFLD.
Why the study?
Although NAFLD is an independent risk factor for atherosclerotic cardiovascular disease, the association between the newly defined MAFLD criteria and carotid atherosclerosis remains poorly understood.
Is MAFLD associated with a higher prevalence of concurrent carotid atherosclerosis compared to NAFLD?
Cross-Sectional (n=11,194)
No
Is MAFLD associated with a higher prevalence of concurrent carotid atherosclerosis compared to NAFLD?
Odds Ratio: 2.35
MAFLD is associated with a significantly higher prevalence of concurrent carotid atherosclerosis compared to NAFLD, suggesting it may serve as a better marker for cardiovascular risk.
MAFLD may flag higher carotid atherosclerosis risk in cross-sectional data; leaves open superiority to NAFLD and need for prospective validation.
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Chung et al. (2024) conducted a cross-sectional in Metabolic dysfunction-associated fatty liver disease (MAFLD) (n=11,194). Metabolic dysfunction-associated fatty liver disease (MAFLD) vs. Non-MAFLD patients was evaluated on Concurrent carotid atherosclerosis (OR 2.35). MAFLD was associated with a significantly higher prevalence of concurrent carotid atherosclerosis compared to non-MAFLD patients (65.5% prevalence; OR 2.35).
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