Population
Experimental endocarditis models
Comparison
Neutralization of platelet… vs Expressed PAAP
Design
Review
Authors
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Does not yet support PAAP-targeted therapies clinically; leaves open translation from experimental models to human endocarditis.
The platelet aggregation-associated protein (PAAP) of Streptococcus sanguis plays a direct role in the pathogenesis of infective endocarditis by promoting platelet accumulation and vegetation formation.
Mark C. Herzberg (1996) studied this question.
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