Key result
An elevated serum uric acid level was associated with a higher likelihood of left atrial thrombus or spontaneous echo contrast (OR 1.59; 95% CI 1.13-2.23; P=0.008).
Why the study?
Does an elevated serum uric acid level predict the presence of left atrial thrombus or spontaneous echo contrast detected by transesophageal echocardiography?
Meta-Analysis (n=2,381)
Does an elevated serum uric acid level predict the presence of left atrial thrombus or spontaneous echo contrast detected by transesophageal echocardiography?
Odds Ratio: 1.59 (95% CI 1.13–2.23)
p-value: p=0.008
Elevated serum uric acid levels are significantly associated with an increased risk of detecting left atrial thrombus or spontaneous echo contrast on transesophageal echocardiography.
Background Recent observational studies have suggested that the patients with hyperuricemia have a higher risk of having left atrial thrombus (LATH) or left atrial spontaneous echo contrast (LASEC) by transesophageal echocardiography (TEE), while the ultimate predictive value of a high uric acid (UA) level on LATH/LASEC remained obscure. Methods We searched the PubMed and Cochrane clinical trials databases up to July 2015. Following screening the 369 initially identified studies, we analyzed six observational studies with 2381 patients. Results The meta‐analysis of these studies showed that an elevated serum UA level was associated with a higher likelihood of LATH/LASEC ( OR = 1.59, 95% CI 1.13–2.23, P = 0.008), while significant differences exist among individual trials ( P < 0.00001 and I 2 = 85%). Sensitivity analysis failed to find any heterogeneity. Conclusion An elevated UA level was associated with a higher risk of detecting a left atrial abnormality represented by LATH/LASEC.
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Zhang et al. (2016) conducted a meta-analysis in Risk of left atrial thrombus or spontaneous echo contrast (n=2,381). Elevated serum uric acid level vs. Normal or lower serum uric acid level was evaluated on Left atrial thrombus (LATH) or left atrial spontaneous echo contrast (LASEC) (OR 1.59, 95% CI 1.13-2.23, p=0.008). An elevated serum uric acid level was associated with a higher likelihood of left atrial thrombus or spontaneous echo contrast (OR 1.59; 95% CI 1.13-2.23; P=0.008).
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