Key result
Having two or more risk factors (hypertension, limited activity, reduced renal function) was associated with a 20% in-hospital mortality rate, nearly eight times higher than having one or none.
Why the study?
What are the causes of and risk factors for in-hospital and long-term mortality in male veterans with or at high risk for coronary artery disease following major noncardiac surgery?
Population
474 men between the ages of 38 and 89 years with known coronary artery disease or at high risk for coronary…
Design
Cohort
Follow-up
up to 2 years
Authors
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Risk stratification may guide perioperative monitoring in veterans; leaves open whether interventions targeting these factors improve outcomes.
Cohort (n=474)
No
What are the causes of and risk factors for in-hospital and long-term mortality in male veterans with or at high risk for coronary artery disease following major noncardiac surgery?
Relative Risk: 8 (95% CI 3.6–16)
In male veterans with or at high risk for coronary artery disease undergoing major noncardiac surgery, noncardiac causes of death are more common than cardiac causes, and specific risk factors strongly predict in-hospital mortality.
Warren S. Browner (1992) conducted a cohort in Major noncardiac surgery in patients with or at high risk for coronary artery disease (n=474). Two or more risk factors (hypertension, severely limited activity, creatinine clearance <0.83 mL/s) vs. One or no risk factors was evaluated on In-hospital mortality (RR 8.0, 95% CI 3.6-16). Having two or more risk factors (hypertension, limited activity, reduced renal function) was associated with a 20% in-hospital mortality rate, nearly eight times higher than having one or none.
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