July 22, 2011Journal of the American Chemical Society147 citations

Total Synthesis of Bryostatin 7 via C–C Bond-Forming Hydrogenation

YLYu Lu SWSang Kook Woo MKMichael J. Krische

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Abstract

The marine macrolide bryostatin 7 is prepared in 20 steps (longest linear sequence) and 36 total steps with five C-C bonds formed using hydrogenative methods. This approach represents the most concise synthesis of any bryostatin reported, to date.

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synapsesocial.com/papers/6a227536ac77194489b714df https://doi.org/https://doi.org/10.1021/ja205673e

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