Total Synthesis of Bryostatin 3

A convergent synthetic strategy has been used to accomplish the first total synthesis of the title compound 1, a γ-lactone-containing member of the antineoplastic marine macrolide family. The C1−C16 and C17−C27 fragments were combined by the Julia–Lythgoe olefination and the Yamaguchi macrolactonization. This was followed by the stereoselective introduction of a methoxycarbonylmethylene group, and final hydrolysis of the acetal provided access to the target molecule 1.